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Director, medicinal chemistry

Arrowhead Pharmaceuticals

This is a Full-time position in Verona, NJ posted November 29, 2019.

The PositionThe Director, Medicinal Chemistry will be a key member of the drug discovery team at Arrowhead’s Madison, WI-based Research and Development facility and will lead multiple internal and/or partnered drug discovery programs based on the company’s RNAi-based platform technology.

The candidate will contribute to overall drug discovery strategy and pipeline prioritization and will drive medicinal chemistry strategy.

Significant experience with structure-based drug design, research project management and tract record of developing candidates to enter the clinic is desired. ResponsibilitiesProvide scientific leadership, from a medicinal chemistry perspectiveSupervise a small team of synthetic chemistsEstablish new drug discovery targets and projectsLead internal and external discovery projects to help achieve departmental and site-wide milestone and goals Provide expert insight into targeting ligands and design strategy Provide synthetic organic expertise to enable novel synthetic routes to novel molecules of interest Network and collaborate across Chemistry and Biology departments to integrate discovery efforts Present work at departmental and site-wide meetings Contribute to regulatory filings, scientific publications and conference proceeds, as appropriate Requirements:PhD degree with at least 10 years of drug discovery experience in pharmaceutical industry Demonstrated achievement in synthesis and design of bioactive compoundsExtensive knowledge in synthetic organic chemistry, both theoretical and practical Solid understanding of pharamcology, PKPD and ADME conceptsExperience in lead optimization, SAR analysis and drug design Excellent oral and written communication skills